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Denver erased a 16-point halftime deficit, went ahead on Bo Nix’s one-yard touchdown run with 47 seconds left and sealed the win with Talanoa Hufanga’s second interception.
Brock Purdy threw four touchdowns, Minnesota held off Tampa Bay and Las Vegas scored the final 19 points to beat New Orleans.
Baltimore answered Dallas’ tying field goal with a Jackson-to-Flowers completion and Tyler Loop’s winning kick as time expired in Rio de Janeiro.
Jahmyr Gibbs caught the go-ahead touchdown with 2:25 left before Chuck Clark’s strip-sack ended New York’s final drive.
Spencer Shrader kicked four field goals despite a groin injury as Indianapolis earned its first victory of the season and dropped Houston to 0–3.
Josh Allen ran for two touchdowns, James Cook III rushed for 154 yards and Buffalo’s defense rescued a 24–16 victory.
Aaron Rodgers threw three touchdown passes before Pittsburgh’s defense ended Cincinnati’s final drive, handing the Bengals their first loss.
Kenneth Walker III scored twice and Travis Kelce supplied the late clincher in Kansas City’s 24–10 victory at Miami.
New York ruled out its leading running back after a fourth-quarter tackle in Detroit; no recovery timetable was immediately available.
Baltimore had two key starters available against Dallas, while a toe injury kept left tackle Ronnie Stanley out of the lineup.